For example, the retrograde signaling that involves the transcriptional regulator Myc (the protein overexpressed in over 70% of all human cancers and a structural homolog of Rtg1p, [15]) can affect a variety of processes, such as the cell cycle, cell death, cell adhesion and cellular metabolism, including glutaminolysis and metabolic pathways that provide precursors for biosynthetic reactions [39]. This evidence concerns the gene MYC and cancer.