E2F8 and breast cancer: Notably, E2F8 expression also significantly correlated with overall survival in breast cancer patients with clinical stage 1 + 2 subgroup (n = 128, P = 0.001; Figure 2C), as well as clinical stage 3 + 4 subgroup (n = 59, P = 0.039; Figure 2D), suggesting that E2F8 might be a valuable prognostic marker for breast cancer patients at all disease stages.