Moreover, E2F8 expression levels were positively correlated with Ki67 expression from both TCGA mRNA data set (r = 0.817, P < 0.001) and our IHC results (P < 0.001) (Figure 3B, 3C), suggesting that E2F8 may contribute to cell proliferation in breast cancer. This evidence concerns the gene MKI67 and breast carcinoma.