For instance, Carotenuto et al. showed that h-prune interaction with GSK-3β, which impairs the ability of GSK-3β to phosphorylate β-catenin, activates the Wnt/β-catenin pathway and enhances cancer progression in non–small cell lung cancer (NSCLC) [29]. Here, GSK3B is linked to non-small cell lung carcinoma.