Considering that HPV infection is an early event in the establishment of cervical cancer and as DEPTOR is not directly regulated by HPV oncoproteins E6/E7, we therefore hypothesize that action of DEPTOR to be a late molecular event in the pathogenesis or progression of cervical SCC, possibly beyond the severe dysplasia stages leading to carcinoma in situ. This evidence concerns the gene DEPTOR and cervical cancer.