Additionally, we found lncRNA Ftx or miR-545 led to upregulation of cell cycle regulator Cyclin D1 and downregulation of p27 through activation of PI3K/Akt in vitro and vivo. Collectively, our results demonstrate that lncRNA Ftx/miR-545 axis promotes HCC progression through activation of Akt signaling pathway by targeting RIG-I. Here, FTX is linked to hepatocellular carcinoma.