In multivariate analysis, EGFR mutations were frequent in women (OR: 1.83, P<0.001), middle-aged patients (OR: 1.34, P<0.001), those who never smoked (OR: 2.04, P<0.001), adenocarcinomas (OR: 14.0, P<0.001), well (OR: 2.46, P<0.001) to moderately (OR: 2.73, P<0.001) differentiated tumors, small-sized tumors (OR for 1cm increase: 0.91, P=0.003), tumors of non-mucinous type (OR: 26.8, P<0.001), tumors without signet ring cells (OR: 17.2, P=0.007), and tumors with lepidic (OR: 2.18, P=0.003), acinar (OR: 3.38, P<0.001) and papillary (OR: 3.17, P<0.001) patterns (Table S5 and Figure S3). This evidence concerns the gene EGFR and adenocarcinoma.