KRAS and adenocarcinoma: In multivariate analysis, KRAS mutations were frequent in men (OR: 1.67, P=0.003), older patients (OR for 1-year increase: 1.03, P<0.001), smokers (OR: 1.78, P<0.001), adenocarcinomas (OR: 7.28, P<0.001), large-sized tumors (OR for 1cm increase: 1.17, P<0.001), poorly-differentiated tumors (vs. moderate differentiation, OR: 1.88, P=0.001), and mucinous type (OR: 9.09, P<0.001) and solid pattern (vs. acinar pattern, OR: 2.57, P<0.001) tumors (Table S7).