As shown in Table 1, CCR2 expression has positive correlation with tumor invasion depth (P=0.006 and P=0.004, respectively), lymph node metastasis (P=0.038 and P=0.011, respectively) and TNM stage (P=0.003 and P=0.001, respectively) in the two independent sets, while it has no significant correlation with gender, age, tumor differentiation and Lauren classification in the two sets. This evidence concerns the gene CCR2 and metastatic malignant neoplasm in the lymph nodes.