Disruptions interfering with homeostatic regulatory balance causing excessive downregulation of p53 renders cells unequipped to effectively prevent tumor growth; thus, interruptions to the proper regulation between MDM2 and p53 have been associated with a variety of cancers, most notably those in which wild type p53 remains intact [18][19][20][21][22][23][24]. The gene discussed is MDM2; the disease is neoplasm.