Additionally, in this study, we confirmed that LDR prevented diabetic cardiomyopathy at the late‐stage of diabetes and this was because of suppression of diabetes‐induced apoptosis and oxidative stress via the Akt‐mediated MDM2/P53 pathways and the Nrf2/keap1 pathway respectively. This evidence concerns the gene AKT1 and diabetic cardiomyopathy.