Additionally, in this study, we confirmed that LDR prevented diabetic cardiomyopathy at the late‐stage of diabetes and this was because of suppression of diabetes‐induced apoptosis and oxidative stress via the Akt‐mediated MDM2/P53 pathways and the Nrf2/keap1 pathway respectively. The gene discussed is TP53; the disease is diabetic cardiomyopathy.