However, during the late phase of infection, WSX-1/IL-27 seems to play a role in limiting the production of pro-inflammatory cytokines such as IFN-γ (S5B Fig), leading to augmented reduction of parasitemia (S5A Fig), as in the case of infection with lethal P. berghei NK65 [47–49]. Here, IL27RA is linked to parasitic infectious disease.