RPS6KB2 and esophagitis: We found that the AA genotype of RPS6KB2:rs10274 had a protective effect against the risk of esophagitis, and cis-eQTL analysis further supported that the AA genotype of rs10274 is associated with lower expression of the RPS6KB2 gene, while the GG genotype of rs10274 was associated with higher expression of RPS6KB2. Although not yet reported in the literature, it is likely that the A genotype of RPS6KB2:rs10274 itself or SNP tagged by it could create a new miRNA binding site for miR-193a regulation, which would enable the down regulation of miR-193a-3p on the host gene.