However, the role of DICER1 in cancer is complicated as mouse cancer models suggest that loss of one copy of the Dicer1 gene increases tumorigenesis, whereas loss of both copies inhibits it, leading to the idea that DICER1 functions as a haploinsufficient tumor suppressor (Bahubeshi et al., 2011; Foulkes et al., 2014). This evidence concerns the gene DICER1 and cancer.