As reported previously, exposure of the Burkitt’s lymphoma cell line, BJAB, to TRAIL (Dickens et al., 2012a), or HaCaT keratinocytes to CD95L (Kavuri et al., 2011) induced receptor-mediated activation of caspase-8, caspase-3, and apoptotic cell death. Here, CASP8 is linked to Burkitt lymphoma.