At the day of sacrifice, we found comparable clinical scores and NMO-IgG titers, which was ENMO median score 1 with a median antibody titer of 1:80 (range 1:40–1:80; animals killed 12 and 24 hours after IFN-β injection), and ENMO score 2 with a median antibody titer of 1:40 (range 1:20–1:40; animals killed 48 hours after IFN-β injection). The gene discussed is IFNB1; the disease is neuromyelitis optica.