IFNAR1 and neuromyelitis optica: At first glance, there seems to be a discrepancy between the seemingly protective I-IFN signature in ENMO rats culminating in the formation of smaller NMO-like lesions in I-IFN treated ENMO animals, and the formation of larger NMO-like lesions in wildtype mice compared to their IFNAR deficient counterparts, when both were intracerebrally injected with NMO-IgG and complement [16].