IFNAR1 and neuromyelitis optica: However, antibody-dependent cellular cytotoxicity executed by Fc gamma-receptor 3 (Fcgr3)-positive activated microglia, macrophages and neutrophils is an important factor contributing to the formation of astrocyte-destructive lesions in the presence of NMO-IgG and complement [27,28], and neutrophils were found in much lower numbers in the NMO-IgG/complement-injected CNS of the IFNAR deficient mice [16].