SCN1A variants are associated, at the more benign end of the disease spectrum, with the dominantly inherited genetic epilepsy with febrile seizures plus [1, 2] (GEFS+), and, at the severe end, with Dravet syndrome (DS), an epileptic encephalopathy arising from de novo SCN1A mutations in the vast majority of DS patients [3]. The gene discussed is SCN1A; the disease is Epileptic encephalopathy.