IL6 and obesity due to melanocortin 4 receptor deficiency: Alterations in the levels of adipokines including a decrease in adiponectin (Berg et al., 2002) and increases in leptin (Wauman & Tavernier, 2011) and IL‐6 (Vozarova et al., 2001) are primary links between obesity and systemic inflammation, as well as signs of progression of metabolic dysfunction.