Alterations in the levels of adipokines including a decrease in adiponectin (Berg et al., 2002) and increases in leptin (Wauman & Tavernier, 2011) and IL‐6 (Vozarova et al., 2001) are primary links between obesity and systemic inflammation, as well as signs of progression of metabolic dysfunction. Here, LEP is linked to obesity due to melanocortin 4 receptor deficiency.