Other factors associated with a significant increased risk of progression from MCI to dementia were multi-domain MCI (HR, 3.4; 95% CI 1.0 to 11.4), vascular lesions at neuroimaging (HR 3.0; 95% CI 1.0 to 8.9) and the presence of at least one APOE-ε 4 allele (HR, 2.4; 95% CI 1.0 to 6.0). The gene discussed is APOE; the disease is dementia.