CALR and essential thrombocythemia: The pathogenetic hallmark of MPNs is the hyperactivation of the JAK/STAT signaling pathway.25, 26 This deregulation is usually associated with the JAK2V617F mutation, but also with mutations in the CALR and MPL genes that are also involved in the development of MPNs, and specifically in ET.7, 27, 28 In the present work, we focused in the identification of miRNAs of the JAK/STAT pathway associated with the JAK2V617F mutation.