Etanercept is a recombinant protein constructed by fusing human soluble p75 TNF receptors (extracellular domain) to human IgG1 Fc (TNFR-Fc), and has been used to ameliorate rheumatoid arthritis symptoms [7] and ankylosing spondylitis [8]. The gene discussed is TNFRSF1A; the disease is rheumatoid arthritis.