While we did not observe any difference in collagen organization in 4T1 or RM11 tumors, neither with SEM nor with picrosirus-red staining, Navab et al [10] found that collagen had a more non-linearized pattern in NSCLC tumors in α11-KO mice using different approaches, namely picrosirius-red staining, second harmonic generation imaging and atomic force microscopy. This evidence concerns the gene IGKV3D-20 and non-small cell lung carcinoma.