For example, a pathogenic retrotransposon insertion in the 3'UTR of the Fukutin gene leads to the development of Fukuyama-type congenital muscular dystrophy [29], whereas an ATn dinucleotide repeat polymorphism within the CTLA-4 gene has been shown to be protective against development of Graves' Disease in childhood [35]. This evidence concerns the gene CTLA4 and Congenital muscular dystrophy, Fukuyama type.