DAG1 and adenocarcinoma: In adenocarcinoma, the extracellular α‐subunit of dystroglycan that interacts directly with laminin and other LG domain extracellular matrix proteins is frequently hypo‐glycosylated [Shimojo et al., 2011] due to transcriptional silencing of LARGE, a key glycosyltransferase required for the addition of O‐linked glycan moieties essential for the laminin G domain interaction (de Bernabe et al., 2009; Esser et al., 2013).