In addition, S1P‐deficient mice have increased vascular leakage and mortality after anaphylaxis compared to control mice 29 and rats have reduced loss of plasma volume during sepsis after administration of the S1P‐analogue FTY720 30, indicating a role for S1P‐regulated events in the pathology of plasma leakage. The gene discussed is MBTPS1; the disease is anaphylaxis.