The UBQLN4 homologs UBQLN1 and UBQLN2 have been implicated in the pathogenesis of neurodegenerative diseases, i.e. Parkinson’s, Alzheimer’s, Huntington's, and amyotrophic lateral sclerosis/frontotemporal dementia [18]. The gene discussed is UBQLN2; the disease is frontotemporal dementia.