Interestingly, the ubiquilin-2 sequence 461-GLQTLATEAPGLIPS-475 aligns with ubiquilin-4 475-GLQTLQTEAPGLVPS-489, and therefore the UDP patient’s heterozygous variant and the FTD-associated homozygous variant are adjacent in the aligned sequence. The gene discussed is UBQLN2; the disease is frontotemporal dementia.