MEN1 and pancreatic neuroendocrine tumor: The rate of apoptosis in the pancreatic and pituitary NETs was assessed by TUNEL analysis, and in pancreatic NETs the mean (±SEM) apoptosis rate in pasireotide-treated Men1+/− mice was significantly higher than that in PBS-treated Men1+/− mice (0.42 ± 0.05 vs 0.19 ± 0.03%; P < .001; Figure 6B).