Among them, 54 were excluded for the following reasons: we could not obtain full text for one study, 18 publications were reviews, 27 studies did not evaluate the diagnostic or prognostic value of GDF15 in CRC, data from five studies were incomplete and three studies use other methods, like RT‐PCR or IHC to detect GDF15 levels. The gene discussed is GDF15; the disease is colorectal carcinoma.