PKM and neoplasm: Furthermore, a significant association between tumour cell proliferation and expression of both PKM2 and LDHA was observed; the number of tumour nuclei expressing Ki-67 was more than 2-fold higher in PKM2 and LDHA expressing tumours compared with negative tumours (PKM2: 27.8 ± 12.9 vs. 12.2 ± 14, p = 0.0001 and LDHA: 25.1 ± 14 vs. 12.3 ± 15.1, p = 0.004).