TP53 and familial pancreatic carcinoma: Very recently, Rajeshkumar et al (2015) found that the LDHA small molecule inhibitor FX11 can impede tumour growth, reduce tumour cell proliferation and induce apoptosis in a patient-derived mouse xenograft model of pancreatic cancer with mutant TP53, while tumours harbouring wild-type TP53 were completely resistant to FX11 [56].