PKM and neoplasm: Among the several survival predictors by the univariate analysis (T-stage; p = 0.006, tumour differentiation; p = 0.003, metastatic status; p = 0.000), by Cox regression analysis only the combined PKM2 / LDHA expression status and tumour differentiation status were independent survival predictors (p = 0.003, Hazard ratio (HR) = 4.96 and p = 0.015, HR = 3.31, respectively) (Table in S1 Table).