Other plasma proteins whose levels positively correlate with ventricular remodelling are tissue plasminogen activator (t-PA) [58], a fibrinolytic enzyme that might play a causative role in postreperfusion intramyocardial hemorrhage [108] and that might contribute to extracellular matrix remodelling [109], terminal peptides derived from procollagen [58], some markers of systemic inflammation such as interleukin-1β and C-reactive protein (CRP) [58, 110], and some growth factors, such as hepatocyte growth factor (HGF), and growth differentiation factor-15 (GDF-15) [58]. Here, GDF15 is linked to hemorrhage.