Free fatty acids cause both insulin resistance and inflammation in the major insulin target tissues (skeletal muscle, liver and endothelial cells) and thus are an important link between obesity, insulin resistance, inflammation and the development of type 2 diabetis, hypertension, dyslipidemia, disorders of coagulation and atherosclerotic vascular disease [38]. This evidence concerns the gene INS and obesity due to melanocortin 4 receptor deficiency.