REN and Hyperglycemia: Originally, Rubler et al. in 1972 [4], based on postmortem findings, proposed that diabetic cardiomyopathy is secondary to underlying hyperglycemia resulting in a multitude of adverse downstream effects, including impaired myocyte calcium handling, renin-angiotensin-aldosterone activation, microangiopathy, myocardial fibrosis, and increased oxidative stress [5–7].