Based on these findings, it appears that hyperglycemia and elevated Ang II associated with diabetes work via the AT1 receptor to increase TNF-α levels and NADPH oxidase activity, while ExT suppresses expression of TNF-alpha and thus offers a potential protection against TNF-alpha-induced insulin resistance [82] and increased ROS production [83, 84]. The gene discussed is AGTR1; the disease is Hyperglycemia.