PRKDC and bacterial infectious disease: The top three enriched targets are dihydrofolate reductase (DHFR), which plays a role in bacterial infection and cancer [90] (ES = 0, AR = 0.0532), DNA-dependent protein kinase catalytic subunit (DNA-PKCs), which is implicated in cancer [91] (ES = 0, AR = 0.0644), and tumour necrosis factor (TNF), which is found to exert activities in cancer, inflammation, and bacterial infection [92, 93] (ES = 0, AR = 0.0687).