The top three enriched targets from cluster X are mainly implicated in immunomodulation, namely, steryl-sulfatase (STS) [65], tyrosine-protein phosphatase nonreceptor type 2 (PTPN2) [66], and peptidyl-prolyl cis-trans isomerase FKBP1A (FKB1A) [67], glucose homeostasis, such as sodium glucose transporter 1 (SGLT1) and sodium glucose transporter 2 (SGLT2) [68], cancer, such as DNA topoisomerase 1 (TOPO1) [69], reproductive system, such as testosterone 17-beta-dehydrogenase 3 (17-beta-HSD 3) [70], and central nervous system (CNS), such as glutamate carboxypeptidase 2 (CGPII) [71]. Here, TOP1 is linked to cancer.