PTPN2 and cancer: Overall the top three enriched targets in the cluster can be classified into immunomodulation, which are PTPN2 [66], protein kinase C beta type (PKC-β) [82], protein kinase C eta type (PKC-η) [83], and protein kinase C gamma type (PKC-γ) [84], cancer, namely, TOPO1 [69], and glucose homeostasis, such as SGLT2 [68].