Once NF-κB has been activated through one of many pathways, crucial properties of the malignant phenotype are activated, promoting tumor cell adaptation to the tumor environment [41]; then, we also reported NF-κB overexpressed in female dogs with tumor masses greater than three centimeters, lymph node involvement, recurrence, and clinical stage III or IV, leading to a poor survival rate of the animals. This evidence concerns the gene NFKB1 and neoplasm.