IL6 and neoplasm: In contrast, IL-6 was significantly overexpressed in animals aged > 10 years (p = 0.03) and animals with multiple tumor locations (p = 0.0005); abundant tumor vascularization (p = 0.003); tumor mass size greater than three centimeters (p = 0.01); lymph node involvement (p = 0.04); metastasis (p = 0.003); recurrence (p = 0.03); and clinical stage III or IV (p = 0.02) and animals that died during followup (p = 0.008) (Figure 5(a)).