TNF and breast cancer: In this way, the objective of this work was to ascertain the role of anti-inflammatory cytokines, IL-4 and IL-10, and proinflammatory cytokines, IL-6 and TNF-α, in mammary tumors of female dogs and to correlate these results with the gene and protein expression of NF-κB. In addition, we sought to verify the correlation of these cytokines with clinicopathological parameters, cancer progression, and overall survival, to determine their prognostic value in mammary tumors.