CEACAM5 and esophageal squamous cell carcinoma: ROC curve analysis showed that plasma miRNA-216a/b exhibited satisfactory diagnostic value for ESCC, with AUC of 0.877 (95% CI: 0.818–0.922) for miRNA-216a and 0.756 (95% CI: 0.685–0.819) for miRNA-216b, which were higher than conventional biomarkers such as SCC-Ag (AUC: 0.665) and CEA (AUC: 0.549) reported in other studies [13, 16].