TET1 and cephalocele: Nearly all affected mice (48/50) exhibiting one of the craniofacial traits from adults, newborns (ocular hypertelorism, cranial cephalocele, bifid nose, midfacial cleft or anencephaly) and embryos with neural tube closure defects that we previously described (Fong et al., 2014) were homozygous for the c.5167C>T mutation in the Tet1 gene (Tet1tuft/tuft).