The PI3K/AKT/mTOR signaling pathway is the most frequently activated signaling network in cancer and recurring mutations in this network have been identified, including mutations (PIK3CA, AKT, and PTEN), amplifications (PIK3CA, PIK3CB and AKT) and deletions (PTEN, INPP4B) [7–12]. The gene discussed is PIK3CB; the disease is cancer.