HMGB1 and neoplasm: Taken together, these data suggest that hypoxia exacerbates secretion of HMGB1 from GemOE cells, in vitro and in vivo and that whether actively secreted from surviving/hypoxic or passively diffused from dying/necrotic GemOE cells in vitro or GemOE cells within tumor cores in vivo HMGB1 is acetylated.