AGER and neoplasm: Taken together, the data clearly show that Ac-HMGB1 released from the chromatin that accumulates in the cytoplasm of GemOE cells (Figure 2A) is rapidly released (Figure 2B and 2C) to promote survival of GemOE tumor cells by activating NF-κB (Figure 2D) in an autocrine/paracrine fashion through binding to RAGE expressed on the surface of these cells (The kinetics of this is shown in Figure 2G).