Together re-enforces the aforementioned conclusion that induction in CXCR4 expression on the surface of naïve MSCs is directly controlled by Ac-HMGB1 activation of RAGE in vitro and in vivo and suggest that GemOE cells through secreting Ac-HMGB1 recruit MSCs to their vicinity in tumor cores. The gene discussed is HMGB1; the disease is neoplasm.