HMGB1 and neoplasm: Furthermore, although we could not detect a significant difference in the level of HMGB1 between normal and tumor tissues, it was absolutely clear that geminin-negative/cytoplasmic c-Abl-overexpressing tumors express nuclear HMGB1 (Figure 3C), whereas in total agreement with the above data, almost all geminin-positive/nuclear c-Abl-overexpressing tumors express cytoplasmic HMGB1 (Figure 3F).