We propose that similar to in vitro data, in vivo GemOE cells recruit MSCs to their vicinity through secreting Ac-HMGB1 that promotes expression and activation of RAGE, which in turn induces CXCR4 expression in MSCs that responds to high levels of SDF1 secreted from GemOE tumor cells. The gene discussed is CXCL12; the disease is neoplasm.