EGFR and colorectal carcinoma: The EGFR-targeting antibodies cetuximab, a chimeric IgG1 monoclonal antibody, and panitumumab, a humanized IgG2 monoclonal antibody, have proven effective against CRC in clinical trials and have been used either individually or in combination with standard chemotherapy to improve survival in metastatic CRC (mCRC) patients [7–8].