SMAD7 and hepatocellular carcinoma: While using RNA structure website (http://rna.urmc.rochester.edu/RNAstructureWeb/), we found the variation these loci with resulted in the change of secondary structures and influence on the stabilities of SMAD7 RNA, which will then influence the functions of SMAD7. Vascular invasion is the most important predictor of survival in HCC, thus, a link to vascular invasion means these 2 SNPs potentially could be the predictor of survival in HCC [31].