The ability of DKK‐1 autoantibodies to diagnose ESCC or early‐stage ESCC was evaluated by ROC analysis, and the results suggested that DKK‐1 autoantibody may serve as a diagnostic biomarker for ESCC (cutoff value: 0.522, Fig. 2, Table 2). Here, DKK1 is linked to esophageal squamous cell carcinoma.