With respect to leukaemia, sphingolipids are studied due to their part in the process of lymphocyte release into the circulation; leukemic clonal exit is modulated by the expression of sphingosine-1-phosphate receptor 1 (S1PR1) and levels of S1P in plasma of non-diseased subjects are normally high to instigate the migration of lymphocytes into circulation. Here, S1PR1 is linked to leukemia.