Indeed, the more aggressive phenotype granted by MAPK15 overexpression to NTera2/D1 cells nicely fits with the evidence that MAKP15 levels positively correlate to germ cell tumor malignancy in patients, being this kinase downregulated in the more benign teratomas and upregulated in the malignant EC. The gene discussed is MAPK15; the disease is testicular germ cell tumor.