MAPK8 and Parkinson disease: ER stress-induced apoptosis is implicated in various pathological conditions, but the mechanisms of H. erinaceus mycelium on the suppression of oxidative stress and JNK/p38 MAPK as well as Fas, Bax and CHOP protein expression, which confer neuroprotection in PD involving ER stress–mediated signaling to neuron apoptotic pathways, remain unclear.