Based on our findings that DEK enhances VEGF expression in HIF-1α-dependent and -independent manners, and DEK-enhanced VEGF controls HUVEC proliferation, migration and tube formation as well as angiogenesis in the chick chorioallantoic membrane, we tested the effects of DEK on tumor angiogenesis and growth, and the roles of HIF-1α in these processes. The gene discussed is VEGFA; the disease is neoplasm.