Concerning the possible mechanism for this SNP-SNP interaction, as miRNA could combine the 3’-untranslated region of the targeted gene, PGC protein could protect the mucosal epithelial cell [10], thus, individuals carrying the dual variation in miRNA and PGC gene might cause the decreasing protection function to gastric mucosa and thus increase the risk of gastric cancer. Here, PGC is linked to gastric cancer.