We further analyzed the three-way interaction of miRNA SNPs, PGC SNPs, and H. pylori infection, and found that the miR-4795 rs1002765 – PGC rs9471643 – H. pylori (+) combination was positively associated with AG risk and the let-7e rs8111742 – PGC rs6458238 – H. pylori (+) combination was positively associated with GC risk. Here, PGC is linked to gastric cancer.