Strikingly, when we stained the tumor slices with a monoclonal anti-CD31 antibody to evaluate the status of tumor angiogenesis, we found that tumors from SPC-A1 xenograft mice treated with scFv-9R/HER2si showed a lower level of CD31 expression than the ones from the control groups (Supplementary Figure 5). The gene discussed is PECAM1; the disease is neoplasm.