Some genes that were activated by NF-κB in L1236 cells and identified as classical HL signatures were also upregulated in other B-cell lymphomas, where NF-κB activation has been observed previously, such as nodular lymphocyte-predominant HL (NLPHL) [28], T cell-rich B cell lymphoma (TCRBL) [28] and DLBCL [30] (Fig. 7). This evidence concerns the gene NFKB1 and B-cell non-Hodgkin lymphoma.