Within B-lymphoid malignancies, constitutive NF-κB activation has been identified in classical Hodgkin lymphoma (HL) and - to various degrees - in non-Hodgkin lymphomas including diffuse large B-cell lymphoma, mucosa-associated lymphoid tissue lymphoma, primary effusion lymphoma, adult T-cell lymphoma/leukemia, and multiple myeloma [13, 15]. Here, NFKB1 is linked to diffuse large B-cell lymphoma.