In order to compare the gene sets regulated by the p50/RelA and p52/RelB subunit combinations, reflecting canonical and non-canonical NF-κB signaling in HL cells in vitro, with primary human lymphoma, we performed a retrospective analysis of microarray datasets generated from micro-dissected Hodgkin/Reed Sternberg (HRS) cells of classical HL, other malignant B cell lymphomas, and normal B cells at various stages of differentiation [28, 29]. The gene discussed is RELB; the disease is B-cell non-Hodgkin lymphoma.