MAPKAPK3 and lung adenocarcinoma: Endogenous methylation of MAPKAPK3 at K355 was observed in human SW1990 PDAC cells as well as human H358 and H441 lung adenocarcinoma cells, and this signal decreased upon RNAi-mediated depletion of SMYD2 (Fig. 3C; Supplemental Fig. S5D).