PRMT5 and lung adenocarcinoma: In searching for genes that mediate PRMT5 and WDR77 functions in lung cancer cells, we performed DNA microarray analysis (GSE56757) with lung adenocarcinoma A549 cells expressing WDR77 or PRMT5 shRNA [32, 31] and found that the loss of WDR77 or PRMT5 expression significantly up-regulated GLIPR1 expression.