Future studies of the functional linkage between the deregulated miRNAs and their target genes could indicate that Toll‐like receptor signalling pathway, cAMP signalling pathway, TGF‐beta signalling pathway, MAPK signalling pathway and other pathways are involved in LPS‐induced periodontitis, perhaps providing a better understanding of the molecular mechanisms of LPS‐induced periodontitis. Here, TGFB1 is linked to periodontitis.