IGF1 and acute lymphoblastic leukemia: For instance, Trimarchi et al. found a specific Notch-regulated lncRNA, LUNAR1, can enhance IGF1R mRNA expression andsustain IGF1 signaling in efficient T-ALL growth, and confirmed that lncRNAs are important regulators of the oncogenic state in T-ALL13.Serum lncRNA LIPCAR is considered a novel biomarker of cardiac remodeling and is predictive of mortality in heart failure patients11.